Stuart Close was born on November 24, 1860 in Wisconsin, United States. In 1879 while Close was reading law his father died and his mother then remarried to one San Francisco's leading homeopathic practitioners. It was at this point that Dr. Stuart Close thought of studying homeopathy and his stepfather then furnished him with a comprehensive training in Samuel Hahnemann's Organon. In 1885 he graduated from the Medical College of the Pacific. His career is noted for its exactitude according to Hahnemann's principles. The dedication and exactness with which Dr. Close pursued Hahnemann's teachings won him high praise with the latter's followers. He wrote extensively for the medical press on medico-philosophical subjects, and delivered addresses before many medical societies.